abstract：BACKGROUND:Heart failure (HF) dramatically affects the lives of both patients and their caregivers, yet limited research exists examining the relationship between emotional well-being of HF patients and their caregivers. Therefore, we conducted a study to (1) describe and compare the emotional well-being of HF patients...

journal_title：Journal of cardiac failure

authors： Evangelista LS,Dracup K,Doering L,Westlake C,Fonarow GC,Hamilton M

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Patients with chronic heart failure (CHF) complain of breathlessness and fatigue on exertion, have reduced peak oxygen consumption (pV(O(2))), and an increased ventilatory response to exercise (V(E)/V(CO(2)) slope). These limitations correlate with abnormalities of spirometry (forced expiratory volume in 1 s...

journal_title：Journal of cardiac failure

authors： Witte KK,Morice A,Clark AL,Cleland JG

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Members of the nuclear receptor family proteins function as transcription factors upon ligand binding and thereby regulate gene expression in host cells. Aldosterone, the high-affinity endogenous ligand for the mineralocorticoid receptor, induces cardiac hypertrophy and fibrosis in a variety of animal models...

journal_title：Journal of cardiac failure

authors： Wang J,Yu L,Solenberg PJ,Gelbert L,Geringer CD,Steinberg MI

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Idiopathic giant cell myocarditis (GCM) is an uncommon cause of cardiac failure distinguished clinically from lymphocytic myocarditis by rapidly progressive heart failure, arrhythmias, and heart block. Unlike fulminant lymphocytic myocarditis, patients with fulminant cardiac failure caused by GCM may respond...

journal_title：Journal of cardiac failure

authors： Shields RC,Tazelaar HD,Berry GJ,Cooper LT Jr

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:The gene for cardiac troponin T (TNNT2) is 1 of 7 autosomal disease genes implicated in familial dilated cardiomyopathy (FDC). Identical deletions in exon 13 of TNNT2 have been reported in 2 families with FDC, but little is known about the frequency of this deletion among patients with FDC and idiopathic dil...

journal_title：Journal of cardiac failure

authors： Hanson EL,Jakobs PM,Keegan H,Coates K,Bousman S,Dienel NH,Litt M,Hershberger RE

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:The effect of hospital quality of care on hospital readmission for patients with congestive heart failure (CHF) has not been widely studied. METHODS AND RESULTS:We examined the effects of clinical factors, hospital quality of care, and cardiologist involvement on 3-month readmission rates in patients with C...

journal_title：Journal of cardiac failure

authors： Polanczyk CA,Newton C,Dec GW,Di Salvo TG

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Interleukin (IL)-1 has profound effects on nonimmune cells and organs, including the heart. The effects of IL-1 on transgenic hearts have not yet been described. METHODS AND RESULTS:We generated transgenic mice overexpressing the human IL-1 gene under control of the cytomegalovirus enhancer/chicken beta-act...

journal_title：Journal of cardiac failure

authors： Isoda K,Kamezawa Y,Tada N,Sato M,Ohsuzu F

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:It was not until 1919 that the diuretic properties of mercury were observed in patients with syphilis; in the same year the beneficial effects of mercurial diuretics were shown in a patient with severe rheumatic heart disease and anasarca. However, mercury had been used much earlier for the treatment of drop...

journal_title：Journal of cardiac failure

authors： Ventura HO,Mehra MR,Young JB

更新日期：2001-09-01 00:00:00

abstract：:Beta-adrenergic blocking agents are standard treatment for patients with mild-to-moderate heart failure. When patients receiving beta-blockers decompensate they often need treatment with a positive inotropic agent. The beta-agonist dobutamine may not produce much increase in cardiac output during full-dose beta-blocke...

journal_title：Journal of cardiac failure

authors： Bristow MR,Shakar SF,Linseman JV,Lowes BD

更新日期：2001-06-01 00:00:00

abstract：:Clinical trials designed to evaluate the effect of drugs and devices on the symptoms and clinical status in chronic heart failure have frequently produced conflicting, inconclusive, or misleading results. These difficulties can be explained by the fact that previous studies have relied on efficacy measures that have i...

journal_title：Journal of cardiac failure

authors： Packer M

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Although there have been many studies on the effects of atrial fibrillation (AF) on cardiac function, few studies have been done on its effects on endothelial function. The present study was designed to examine the effects of AF on endothelial function in human subjects. METHODS AND RESULTS:Changes in forea...

journal_title：Journal of cardiac failure

authors： Takahashi N,Ishibashi Y,Shimada T,Sakane T,Ohata S,Sugamori T,Ohta Y,Inoue S,Nakamura K,Shimizu H,Katoh H,Sano K,Murakami Y,Hashimoto M

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:In vivo administration of norepinephrine fails to cause beta-adrenergic receptor desensitization. However, short-term exposure of cultured cells to norepinephrine induces the phenomenon in vitro. We sought to identify the local regulatory mechanisms responsible for in vivo beta-adrenergic receptor desensitiz...

journal_title：Journal of cardiac failure

authors： Nakamura I,Yoshikawa T,Anzai T,Baba A,Iwata M,Wainai Y,Suzuki M,Ogawa S

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Coenzyme Q10 (CoQ10) is essential for ATP generation and has antioxidant properties. Decreased CoQ10 levels have been reported in human heart failure (CHF), but it remains unclear if this is a conserved feature of CHF. The objective of the study was to determine if tachycardia-induced CHF in the dog is assoc...

journal_title：Journal of cardiac failure

authors： Harker-Murray AK,Tajik AJ,Ishikura F,Meyer D,Burnett JC,Redfield MM

更新日期：2000-09-01 00:00:00

abstract：:Knowledge of left-sided cardiac filling pressures has an important role in the management of patients with chronic heart failure. However, the use of a pulmonary artery catheter to measure pulmonary capillary wedge pressure is generally reserved for hospitalized patients with decompensated heart failure, leaving only ...

journal_title：Journal of cardiac failure

authors： Sanders GP,Mendes LA,Colucci WS,Givertz MM

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Endothelin-1 (ET-1) is a potent vasoconstrictor peptide elaborated by many cell types. Plasma ET-1 levels are significantly augmented in patients and experimental animals with heart failure. Enhanced levels of ET-1 may contribute to myocardial depression and alterations in sympathetic nerve activity in the s...

journal_title：Journal of cardiac failure

authors： McConnell PI,Olson CE,Patel KP,Blank DU,Olivari MT,Gallagher KP,Quenby-Brown E,Zucker IH

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:The beneficial effects of the early use of angiotensin-converting enzyme inhibitors (ACEis) in patients with acute myocardial infarction (MI) are well documented. However, the effects of ACEis in patients with an old MI and preserved cardiac function have not yet been studied. We examined the effects of 12 m...

journal_title：Journal of cardiac failure

authors： Ooie T,Saikawa T,Hara M,Takakura T,Sato Y,Sakata T

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Heart failure in blacks has been associated with a poorer prognosis than in whites. In such diseases as hypertension, blacks show pathophysiological differences and respond differently to some therapies than whites. The aim of this study is to evaluate the clinical characteristics and response to therapy of ...

journal_title：Journal of cardiac failure

authors： Carson P,Ziesche S,Johnson G,Cohn JN

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:The present study was designed to study the progression of heart failure in rabbits with catecholamine-induced cardiomyopathy. METHODS AND RESULTS:We investigated the effects of three repetitive applications (at 16-day intervals) of high-dose epinephrine (first infusion, 5 micrograms/kg/min for 60 minutes; ...

journal_title：Journal of cardiac failure

authors： Muders F,Friedrich E,Luchner A,Pfeifer M,Ickenstein G,Hamelbeck B,Riegger GA,Elsner D

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Studies of animal models and human subjects with cardiomyopathies suggest that cardiac myocyte and ventricular chamber remodeling show distinct phenotypic characteristics that may be dependent on specific signaling pathways. METHODS AND RESULTS:In this study, we characterize right ventricular (RV) chamber s...

journal_title：Journal of cardiac failure

authors： Quaife RA,Lynch D,Badesch DB,Voelkel NF,Lowes BD,Robertson AD,Bristow MR

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Exercise training improves endothelium-dependent vasodilation in animals. This study was designed to determine whether forearm exercise training improves endothelium-dependent vasodilation in control subjects and patients with heart failure, a disease associated with abnormal endothelium-dependent vasodilati...

journal_title：Journal of cardiac failure

authors： Bank AJ,Shammas RA,Mullen K,Chuang PP

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Some of the most frequent manifestations of heart involvement in human immunodeficiency virus (HIV) infection include right and left ventricular dysfunction. The pathogenesis remains obscure. METHODS AND RESULTS:This prospective clinical and echocardiographic study involved 181 patients at all stages of HIV...

journal_title：Journal of cardiac failure

authors： Silva-Cardoso J,Moura B,Ferreira A,Martins L,Bravo-Faria D,Mota-Miranda A,Rocha-Gonçalves F,Lecour H,Cerqueira-Gomes M

更新日期：1998-03-01 00:00:00

abstract：:Elevated plasma levels of endothelin (ET) have been reported to accompany the development of heart failure (HF), and therefore, this potent vasoconstrictive peptide has been postulated to contribute to the altered pulmonary hemodynamics that occur in this disease process. The overall goal of this study was to examine ...

journal_title：Journal of cardiac failure

authors： Kribbs SB,Clair MJ,Krombach RS,Hendrick JW,Thomas PB,Keever AT,Houch WV,Mukherjee R,Spinale FG

更新日期：1997-12-01 00:00:00

abstract：:Propionyl-L-carnitine (PLC) is a naturally occurring compound that has been considered for the treatment of congestive heart failure (CHF). The rationale for its use in this pathology is related to its effects on cardiac and skeletal muscle. Chronic treatment with PLC improves the contraction of isolated and aerobic p...

journal_title：Journal of cardiac failure

authors： Ferrari R,De Giuli F

更新日期：1997-09-01 00:00:00

abstract：METHODS AND RESULTS:Over an 18-month period, the patients on the heart transplantation waiting list at our institution were evaluated to determine if continued listing was appropriate. Ten patients were removed because of significant improvement in clinical status and exercise capacity (n = 9) or because of criteria vi...

journal_title：Journal of cardiac failure

authors： Leier CV,Whitby G,Kennedy RA,Binkley PF

更新日期：1997-06-01 00:00:00

abstract：:In most mammalian species, activation of myocardial endothelin as well as alpha1-adrenergic and angiotensin receptors leads to an increase in contractile function and myocardial cell hypertrophy, in association with acceleration of PI hydrolysis and with resultant production of IP3 and diacylglycerol. Therefore, these...

journal_title：Journal of cardiac failure

authors： Fujita S,Endoh M

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:This study was designed to examine the hemodynamic, renal, and hormonal effects of infusion of A-type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in patients with congestive heart failure (CHF). METHODS AND RESULTS:We infused synthetic human ANP or BNP at a rate of 0.1 microgram/kg/ min i...

journal_title：Journal of cardiac failure

authors： Yasue H,Yoshimura M

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:A large V wave in a pulmonary capillary wedge pressure (PCWP) tracing is characteristic of mitral regurgitation. However, the V wave is often increased in patients without or with no significant mitral regurgitation. METHODS AND RESULTS:The V wave was in the PCWP tracing investigated in 65 patients using tr...

journal_title：Journal of cardiac failure

authors： Kageji Y,Oki T,Iuchi A,Tabata T,Ito S

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Some controlled clinical trials showed a beneficial effect of beta-blockers on symptoms, exercise tolerance, and left ventricular function in dilated cardiomyopathy. The purpose of this study was to investigate if there are clinical variables at baseline that could predict a favorable response to long-term m...

journal_title：Journal of cardiac failure

authors： DiLenarda A,Gregori D,Sinagra G,Lardieri G,Perkan A,Pinamonti B,Salvatore L,Secoli G,Zecchin M,Camerini F

更新日期：1996-06-01 00:00:00

abstract：:The aim of this study was to compare the effects on left ventricular function and exercise tolerance of a selective beta-antagonist (atenolol) with those of another selective beta 1-antagonist with vasodilator properties (nebivolol) in patients with ischemic left ventricular dysfunction but no overt congestive heart f...

journal_title：Journal of cardiac failure

authors： Rousseau MF,Chapelle F,Van Eyll C,Stoleru L,Hager D,Van Nueten L,Pouleur H

更新日期：1996-03-01 00:00:00

abstract：:Although atrial fibrillation is common in patients with heart failure, patients with atrial fibrillation are often excluded from congestive heart failure trials or are not analyzed separately. Consequently, while the effect of angiotensin-converting enzyme inhibitors in patients with sinus rhythm is well established, ...

journal_title：Journal of cardiac failure

authors： Van Den Berg MP,Crijns HJ,Van Veldhuisen DJ,Griep N,De Kam PJ,Lie KI

更新日期：1995-12-01 00:00:00

abstract：:Quantitative descriptions of the mechanical restitution curve as a description of variability in ventricular performance with coupling interval in isolated tissue preparations are widely available. In humans, however, in vivo examination of the force-interval relationship is restricted to test pulse intervals shorter ...

journal_title：Journal of cardiac failure

authors： Ritchie RH,Wuttke RD,Hii JT,Jarrett RG,Carey AL,Horowitz JD

更新日期：1995-09-01 00:00:00

abstract：:Studies in patients with moderate heart failure have shown a positive relation between atrial size and plasma atrial natriuretic peptide (ANP)(99-126) concentrations; however, the relation of the hormone level and left atrial size and left ventricular function in patients with severe chronic heart failure has not been...

journal_title：Journal of cardiac failure

authors： Eriksson SV,Caidahl K,Hall C,Eneroth P,Kjekshus J,Offstad J,Swedberg K

更新日期：1995-03-01 00:00:00

abstract：:The authors have previously shown that the resistance ratio (RR) is increased in patients with congestive heart failure (CHF), and that the patients with the highest RRs have an increased mortality. The authors hypothesized that CHF patients with the lowest maximum oxygen consumption and the most impaired Weber functi...

journal_title：Journal of cardiac failure

authors： Mabee SW,Metra M,Reed DE,Dei Cas L,Cody RJ

更新日期：1994-10-01 00:00:00